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KMID : 0604520150410020143
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Journal of the Society of Cosmetic Scientists of Korea
2015 Volume.41 No. 2 p.143 ~ p.150
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Improved One-pot Regioselective Synthesis of 3,7-Diarylpyrazolo[1,5-α]pyrimidines and Their CB1R Activity
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Hong Yong-Deog
Byoun Kyoung-Hee
Park Mi-Young
Park Jun-Seong
Shin Song-Seok
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Abstract
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This study demonstrates an effective one-pot regioselective synthesis of 3,7-diarylpyrazolo [1,5-α]pyrimidines. Moreover, the derivatives obtained were effective CB1R antagonists. These pyrazolo [1,5-α]pyrimidines with diaryl groups at the 3,7-positions are potential pharmacophores for CB1R candidates.
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KEYWORD
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aminopyrazoles, aryl ketoesters, regioselective synthesis, 3, 7-diarylpyrazolo[1, 5-α]pyrimidines
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